Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2449038..2449555 | Replicon | chromosome |
| Accession | NZ_CP094780 | ||
| Organism | Staphylococcus aureus strain IVB6173 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | MUA18_RS12120 | Protein ID | WP_000113260.1 |
| Coordinates | 2449038..2449304 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MUA18_RS12125 | Protein ID | WP_000584499.1 |
| Coordinates | 2449304..2449555 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA18_RS12090 (MUA18_12085) | 2444190..2444726 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| MUA18_RS12095 (MUA18_12090) | 2445248..2446072 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| MUA18_RS12100 (MUA18_12095) | 2446275..2446457 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MUA18_RS12105 (MUA18_12100) | 2446544..2447011 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| MUA18_RS12110 (MUA18_12105) | 2447197..2448744 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUA18_RS12115 (MUA18_12110) | 2448923..2449003 | - | 81 | WP_225539491.1 | hypothetical protein | - |
| MUA18_RS12120 (MUA18_12115) | 2449038..2449304 | - | 267 | WP_000113260.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA18_RS12125 (MUA18_12120) | 2449304..2449555 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA18_RS12130 (MUA18_12125) | 2449720..2449800 | - | 81 | WP_225539489.1 | hypothetical protein | - |
| MUA18_RS12135 (MUA18_12130) | 2449828..2450427 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MUA18_RS12140 (MUA18_12135) | 2450446..2450808 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUA18_RS12145 (MUA18_12140) | 2451063..2452313 | + | 1251 | WP_262541930.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUA18_RS12150 (MUA18_12145) | 2452410..2453141 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA18_RS12155 (MUA18_12150) | 2453138..2453857 | - | 720 | WP_000479579.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.99 Da Isoelectric Point: 10.0373
>T240362 WP_000113260.1 NZ_CP094780:c2449304-2449038 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240362 NZ_LS997868:589192-589479 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATCATTTTCGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGGTGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATCATTTTCGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGGTGTGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT240362 WP_000584499.1 NZ_CP094780:c2449555-2449304 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT240362 NZ_LS997868:588914-589195 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|