Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1437939..1438587 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBMG_RS06830 Protein ID WP_003899414.1
Coordinates 1438264..1438587 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBMG_RS06825 Protein ID WP_003899415.1
Coordinates 1437939..1438184 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS06785 1433087..1433320 - 234 WP_003413717.1 hypothetical protein -
TBMG_RS06790 1433419..1433691 - 273 WP_003900544.1 hypothetical protein -
TBMG_RS21030 1433597..1433986 + 390 WP_003899422.1 hypothetical protein -
TBMG_RS06795 1433983..1434210 + 228 WP_003899421.1 hypothetical protein -
TBMG_RS06800 1434355..1435482 + 1128 WP_003899420.1 site-specific integrase -
TBMG_RS06805 1435485..1435847 + 363 WP_003900543.1 hypothetical protein -
TBMG_RS06810 1435864..1436124 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBMG_RS06815 1436121..1436513 + 393 WP_003899417.1 DUF2742 domain-containing protein -
TBMG_RS06820 1436515..1437942 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBMG_RS06825 1437939..1438184 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBMG_RS06830 1438264..1438587 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBMG_RS21035 1438754..1439245 + 492 WP_003900541.1 phage terminase small subunit P27 family -
TBMG_RS06840 1439398..1439931 + 534 WP_003899412.1 HK97 family phage prohead protease -
TBMG_RS06845 1439939..1441378 + 1440 WP_003899411.1 phage major capsid protein -
TBMG_RS06850 1441549..1441800 - 252 WP_003908028.1 hypothetical protein -
TBMG_RS06855 1441788..1442252 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBMG_RS06860 1442266..1443264 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1434355..1443264 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-67)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T24036 WP_003899414.1 NC_012943:1438264-1438587 [Mycobacterium tuberculosis KZN 1435]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T24036 NC_012943:1438264-1438587 [Mycobacterium tuberculosis KZN 1435]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT24036 WP_003899415.1 NC_012943:1437939-1438184 [Mycobacterium tuberculosis KZN 1435]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT24036 NC_012943:1437939-1438184 [Mycobacterium tuberculosis KZN 1435]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References