Detailed information of TA system TA240355

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1581688..1582267
• Replicon: chromosome
• Accession: NZ_CP094780
• Organism: Staphylococcus aureus strain IVB6173

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUA18_RS07595
• Protein ID: WP_001025401.1
• Coordinates: 1582022..1582267 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1581688..1582053 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA18_RS07555 (MUA18_07550)	1578430..1578987	-	558	WP_000645049.1	DUF2815 family protein	-
MUA18_RS07560 (MUA18_07555)	1579014..1580180	-	1167	WP_233665663.1	DUF2800 domain-containing protein	-
MUA18_RS07565 (MUA18_07560)	1580177..1580539	-	363	WP_000985986.1	hypothetical protein	-
MUA18_RS07570 (MUA18_07565)	1580554..1580877	-	324	WP_000175000.1	hypothetical protein	-
MUA18_RS07575 (MUA18_07570)	1580956..1581117	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
MUA18_RS07580 (MUA18_07575)	1581130..1581393	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MUA18_RS07585 (MUA18_07580)	1581418..1581633	-	216	WP_001097552.1	hypothetical protein	-
MUA18_RS07590 (MUA18_07585)	1581688..1582053	+	366	WP_001128433.1	hypothetical protein	Antitoxin
MUA18_RS07595 (MUA18_07590)	1582022..1582267	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUA18_RS07600 (MUA18_07595)	1582283..1582531	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MUA18_RS07605 (MUA18_07600)	1582695..1583018	+	324	WP_001260486.1	helix-turn-helix transcriptional regulator	-
MUA18_RS07610 (MUA18_07605)	1583031..1583492	+	462	WP_262541840.1	toxin	-
MUA18_RS07615 (MUA18_07610)	1583510..1583944	+	435	WP_031903825.1	hypothetical protein	-
MUA18_RS07620 (MUA18_07615)	1583972..1584367	+	396	WP_001558060.1	hypothetical protein	-
MUA18_RS07625 (MUA18_07620)	1584475..1584666	+	192	WP_252559444.1	hypothetical protein	-
MUA18_RS07630 (MUA18_07625)	1584663..1585241	-	579	WP_252559441.1	hypothetical protein	-
MUA18_RS07635 (MUA18_07630)	1585367..1586572	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1538899..1604203	65304

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240355 WP_001025401.1 NZ_CP094780:c1582267-1582022 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240355 NZ_LS997868:c561345-561067 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATAATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240355 NZ_CP094780:1581688-1582053 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin