Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 347133..347547 Replicon chromosome
Accession NZ_CP094780
Organism Staphylococcus aureus strain IVB6173

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA18_RS01555 Protein ID WP_110166336.1
Coordinates 347133..347384 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA18_RS01560 Protein ID WP_000028424.1
Coordinates 347374..347547 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA18_RS01490 (MUA18_01490) 342297..343082 + 786 WP_262542124.1 ATP-binding protein -
MUA18_RS01495 (MUA18_01495) 343079..343239 + 161 Protein_296 hypothetical protein -
MUA18_RS01500 (MUA18_01500) 343252..343473 + 222 WP_001123695.1 DUF3269 family protein -
MUA18_RS01505 (MUA18_01505) 343484..343888 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA18_RS01510 (MUA18_01510) 343893..344078 + 186 WP_001187242.1 DUF3113 family protein -
MUA18_RS01515 (MUA18_01515) 344079..344696 + 618 WP_262529389.1 SA1788 family PVL leukocidin-associated protein -
MUA18_RS01520 (MUA18_01520) 344696..344953 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA18_RS01525 (MUA18_01525) 344956..345156 + 201 WP_252549766.1 hypothetical protein -
MUA18_RS01530 (MUA18_01530) 345153..345842 + 690 WP_252549763.1 N-6 DNA methylase -
MUA18_RS01535 (MUA18_01535) 345856..346062 + 207 WP_252549760.1 hypothetical protein -
MUA18_RS01540 (MUA18_01540) 346090..346491 + 402 WP_262542127.1 hypothetical protein -
MUA18_RS01545 (MUA18_01545) 346488..346835 + 348 WP_252570428.1 YopX family protein -
MUA18_RS01550 (MUA18_01550) 346832..347053 + 222 Protein_307 hypothetical protein -
MUA18_RS01555 (MUA18_01555) 347133..347384 + 252 WP_110166336.1 DUF1024 family protein Toxin
MUA18_RS01560 (MUA18_01560) 347374..347547 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA18_RS01565 (MUA18_01565) 347548..347829 + 282 WP_000454994.1 hypothetical protein -
MUA18_RS01570 (MUA18_01570) 347830..347991 + 162 WP_000889683.1 hypothetical protein -
MUA18_RS01575 (MUA18_01575) 348006..348539 + 534 WP_025920701.1 dUTP diphosphatase -
MUA18_RS01580 (MUA18_01580) 348576..348782 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA18_RS01585 (MUA18_01585) 348779..348928 + 150 WP_000595265.1 transcriptional activator RinB -
MUA18_RS01590 (MUA18_01590) 348928..349128 + 201 WP_111761860.1 DUF1514 family protein -
MUA18_RS01595 (MUA18_01595) 349151..349612 + 462 WP_086037675.1 hypothetical protein -
MUA18_RS01600 (MUA18_01600) 349727..350179 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA18_RS01605 (MUA18_01605) 350195..350539 + 345 WP_000817289.1 HNH endonuclease -
MUA18_RS01610 (MUA18_01610) 350668..351138 + 471 WP_086037674.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 331464..372897 41433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T240353 WP_110166336.1 NZ_CP094780:347133-347384 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240353 NZ_LS992194:c74260-74102 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240353 WP_000028424.1 NZ_CP094780:347374-347547 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240353 NZ_LS992194:74304-74525 [Escherichia coli]
ATGTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTTTCTGCCACACA
ACACGGTAACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGC
TGACCACACTCACTTTTCCTGAAAATAACCCGCTCATTCAGGCTGTTTACGGGTAATCTGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References