Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2577548..2578071 Replicon chromosome
Accession NZ_CP094778
Organism Staphylococcus aureus strain IVB6185

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA10_RS12880 Protein ID WP_000074047.1
Coordinates 2577548..2577814 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA10_RS12885 Protein ID WP_000587617.1
Coordinates 2577814..2578071 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA10_RS12860 (MUA10_12855) 2572758..2573945 - 1188 WP_000026190.1 MFS transporter -
MUA10_RS12865 (MUA10_12860) 2574339..2575115 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
MUA10_RS12870 (MUA10_12865) 2575108..2575770 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA10_RS12875 (MUA10_12870) 2576116..2577192 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA10_RS12880 (MUA10_12875) 2577548..2577814 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA10_RS12885 (MUA10_12880) 2577814..2578071 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA10_RS12890 (MUA10_12885) 2578431..2578886 + 456 WP_000732090.1 YehR family lipoprotein -
MUA10_RS12895 (MUA10_12890) 2579054..2580631 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA10_RS12900 (MUA10_12895) 2580827..2581576 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA10_RS12905 (MUA10_12900) 2581800..2582993 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240352 WP_000074047.1 NZ_CP094778:c2577814-2577548 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240352 NZ_LS992194:c32643-32494 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240352 WP_000587617.1 NZ_CP094778:c2578071-2577814 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240352 NZ_LS992194:32688-32747 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References