Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2544570..2544754 Replicon chromosome
Accession NZ_CP094778
Organism Staphylococcus aureus strain IVB6185

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA10_RS12735 Protein ID WP_000482647.1
Coordinates 2544647..2544754 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2544570..2544630 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA10_RS12720 (MUA10_12715) 2540080..2540247 - 168 Protein_2459 hypothetical protein -
MUA10_RS12725 (MUA10_12720) 2540478..2542211 - 1734 WP_262607407.1 ABC transporter ATP-binding protein -
MUA10_RS12730 (MUA10_12725) 2542236..2543999 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2544570..2544630 + 61 - - Antitoxin
MUA10_RS12735 (MUA10_12730) 2544647..2544754 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA10_RS12740 (MUA10_12735) 2544888..2545274 - 387 WP_000779351.1 flippase GtxA -
MUA10_RS12745 (MUA10_12740) 2545542..2546684 + 1143 WP_001176855.1 glycerate kinase -
MUA10_RS12750 (MUA10_12745) 2546744..2547403 + 660 WP_000831298.1 membrane protein -
MUA10_RS12755 (MUA10_12750) 2547585..2548796 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
MUA10_RS12760 (MUA10_12755) 2548919..2549392 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-47)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240350 WP_000482647.1 NZ_CP094778:c2544754-2544647 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240350 NZ_LS992194:c2706-2551 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTTACGAATCCGGTAA

Antitoxin


Download         Length: 61 bp

>AT240350 NZ_CP094778:2544570-2544630 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References