Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2519269..2519786 Replicon chromosome
Accession NZ_CP094778
Organism Staphylococcus aureus strain IVB6185

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA10_RS12600 Protein ID WP_000251928.1
Coordinates 2519269..2519535 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA10_RS12605 Protein ID WP_000584497.1
Coordinates 2519535..2519786 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA10_RS12575 (MUA10_12570) 2514476..2515012 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA10_RS12580 (MUA10_12575) 2515480..2516304 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA10_RS12585 (MUA10_12580) 2516507..2516689 - 183 WP_000079140.1 hypothetical protein -
MUA10_RS12590 (MUA10_12585) 2516776..2517243 - 468 WP_250396336.1 SRPBCC domain-containing protein -
MUA10_RS12595 (MUA10_12590) 2517429..2518976 - 1548 WP_045179540.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA10_RS12600 (MUA10_12595) 2519269..2519535 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA10_RS12605 (MUA10_12600) 2519535..2519786 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA10_RS12610 (MUA10_12605) 2519950..2520050 - 101 Protein_2437 hypothetical protein -
MUA10_RS12615 (MUA10_12610) 2520057..2520656 - 600 WP_000162804.1 DsbA family protein -
MUA10_RS12620 (MUA10_12615) 2520675..2521037 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA10_RS12625 (MUA10_12620) 2521292..2522542 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MUA10_RS12630 (MUA10_12625) 2522639..2523370 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA10_RS12635 (MUA10_12630) 2523367..2524086 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240349 WP_000251928.1 NZ_CP094778:c2519535-2519269 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240349 NZ_LS992193:99682-100098 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240349 WP_000584497.1 NZ_CP094778:c2519786-2519535 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240349 NZ_LS992193:99455-99685 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References