Detailed information of TA system TA240349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2519269..2519786
• Replicon: chromosome
• Accession: NZ_CP094778
• Organism: Staphylococcus aureus strain IVB6185

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A170NWK0
• Locus tag: MUA10_RS12600
• Protein ID: WP_000251928.1
• Coordinates: 2519269..2519535 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A166LMC5
• Locus tag: MUA10_RS12605
• Protein ID: WP_000584497.1
• Coordinates: 2519535..2519786 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA10_RS12575 (MUA10_12570)	2514476..2515012	-	537	WP_000024292.1	GNAT family N-acetyltransferase	-
MUA10_RS12580 (MUA10_12575)	2515480..2516304	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
MUA10_RS12585 (MUA10_12580)	2516507..2516689	-	183	WP_000079140.1	hypothetical protein	-
MUA10_RS12590 (MUA10_12585)	2516776..2517243	-	468	WP_250396336.1	SRPBCC domain-containing protein	-
MUA10_RS12595 (MUA10_12590)	2517429..2518976	-	1548	WP_045179540.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA10_RS12600 (MUA10_12595)	2519269..2519535	-	267	WP_000251928.1	Txe/YoeB family addiction module toxin	Toxin
MUA10_RS12605 (MUA10_12600)	2519535..2519786	-	252	WP_000584497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA10_RS12610 (MUA10_12605)	2519950..2520050	-	101	Protein_2437	hypothetical protein	-
MUA10_RS12615 (MUA10_12610)	2520057..2520656	-	600	WP_000162804.1	DsbA family protein	-
MUA10_RS12620 (MUA10_12615)	2520675..2521037	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MUA10_RS12625 (MUA10_12620)	2521292..2522542	+	1251	WP_001012237.1	FemA/FemB family glycyltransferase FmhA	-
MUA10_RS12630 (MUA10_12625)	2522639..2523370	-	732	WP_000615467.1	amino acid ABC transporter ATP-binding protein	-
MUA10_RS12635 (MUA10_12630)	2523367..2524086	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.06 Da
• Isoelectric Point: 10.1628

>T240349 WP_000251928.1 NZ_CP094778:c2519535-2519269 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240349 NZ_LS992193:99682-100098 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9401.54 Da
• Isoelectric Point: 4.3407

>AT240349 WP_000584497.1 NZ_CP094778:c2519786-2519535 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT240349 NZ_LS992193:99455-99685 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A170NWK0

Antitoxin

• AlphaFold DB: A0A166LMC5