Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1625216..1625630 Replicon chromosome
Accession NZ_CP094778
Organism Staphylococcus aureus strain IVB6185

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA10_RS07850 Protein ID WP_250396253.1
Coordinates 1625379..1625630 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA10_RS07845 Protein ID WP_250396254.1
Coordinates 1625216..1625389 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA10_RS07790 (MUA10_07785) 1621467..1621934 - 468 WP_000919026.1 phage terminase small subunit P27 family -
MUA10_RS07795 (MUA10_07790) 1622062..1622406 - 345 WP_000817289.1 HNH endonuclease -
MUA10_RS07800 (MUA10_07795) 1622422..1622874 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA10_RS07805 (MUA10_07800) 1622989..1623459 - 471 WP_045178578.1 hypothetical protein -
MUA10_RS07810 (MUA10_07805) 1623482..1623682 - 201 WP_045178577.1 DUF1514 family protein -
MUA10_RS07815 (MUA10_07810) 1623682..1623831 - 150 WP_000595265.1 transcriptional activator RinB -
MUA10_RS07820 (MUA10_07815) 1623828..1624034 - 207 WP_045178575.1 DUF1381 domain-containing protein -
MUA10_RS07825 (MUA10_07820) 1624031..1624276 - 246 WP_045178573.1 hypothetical protein -
MUA10_RS07830 (MUA10_07825) 1624293..1624466 - 174 WP_001209216.1 hypothetical protein -
MUA10_RS07835 (MUA10_07830) 1624503..1625039 - 537 WP_250396255.1 dUTPase -
MUA10_RS07840 (MUA10_07835) 1625054..1625215 - 162 WP_000889680.1 hypothetical protein -
MUA10_RS07845 (MUA10_07840) 1625216..1625389 - 174 WP_250396254.1 hypothetical protein Antitoxin
MUA10_RS07850 (MUA10_07845) 1625379..1625630 - 252 WP_250396253.1 DUF1024 family protein Toxin
MUA10_RS07855 (MUA10_07850) 1625623..1625907 - 285 WP_250396252.1 hypothetical protein -
MUA10_RS07860 (MUA10_07855) 1625922..1626164 - 243 WP_000132197.1 phi PVL orf 51-like protein -
MUA10_RS07865 (MUA10_07860) 1626168..1626524 - 357 WP_250396251.1 SA1788 family PVL leukocidin-associated protein -
MUA10_RS07870 (MUA10_07865) 1626525..1626710 - 186 WP_001187254.1 DUF3113 family protein -
MUA10_RS07875 (MUA10_07870) 1626715..1627119 - 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA10_RS07880 (MUA10_07875) 1627130..1627345 - 216 WP_262607378.1 DUF3269 family protein -
MUA10_RS07885 (MUA10_07880) 1627358..1627516 - 159 WP_217175976.1 hypothetical protein -
MUA10_RS07890 (MUA10_07885) 1627510..1628283 - 774 WP_017804492.1 ATP-binding protein -
MUA10_RS07895 (MUA10_07890) 1628293..1629096 - 804 WP_016170717.1 phage replisome organizer N-terminal domain-containing protein -
MUA10_RS07900 (MUA10_07895) 1629068..1629307 - 240 Protein_1548 putative HNHc nuclease -
MUA10_RS07905 (MUA10_07900) 1629373..1629924 - 552 WP_000704705.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / sea 1594539..1657224 62685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9447.36 Da        Isoelectric Point: 3.8567

>T240343 WP_250396253.1 NZ_CP094778:c1625630-1625379 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMVSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240343 NZ_LS992192:4760576-4760953 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6469.23 Da        Isoelectric Point: 4.0224

>AT240343 WP_250396254.1 NZ_CP094778:c1625389-1625216 [Staphylococcus aureus]
MSISVGDEVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240343 NZ_LS992192:4760152-4760529 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References