Detailed information of TA system TA240340

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1600467..1600758
• Replicon: chromosome
• Accession: NZ_CP094778
• Organism: Staphylococcus aureus strain IVB6185

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA10_RS07690
• Protein ID: WP_078061146.1
• Coordinates: 1600582..1600758 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1600467..1600523 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA10_RS07650 (MUA10_07645)	1595534..1595680	-	147	WP_001033756.1	hypothetical protein	-
MUA10_RS07655 (MUA10_07650)	1595673..1596587	-	915	WP_000476887.1	DUF1672 domain-containing protein	-
MUA10_RS07660 (MUA10_07655)	1596645..1597550	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
MUA10_RS07665 (MUA10_07660)	1597640..1597855	-	216	WP_045178742.1	hypothetical protein	-
MUA10_RS07670 (MUA10_07665)	1598676..1599167	-	492	WP_045178740.1	staphylokinase	-
MUA10_RS07675 (MUA10_07670)	1599357..1600112	-	756	WP_045178739.1	CHAP domain-containing protein	-
MUA10_RS07680 (MUA10_07675)	1600124..1600378	-	255	WP_045178738.1	phage holin	-
MUA10_RS07685 (MUA10_07680)	1600430..1600530	+	101	Protein_1505	hypothetical protein	-
-	1600467..1600523	+	57	-	-	Antitoxin
MUA10_RS07690 (MUA10_07685)	1600582..1600758	-	177	WP_078061146.1	type I toxin-antitoxin system toxin PepG1	Toxin
MUA10_RS07695 (MUA10_07690)	1600959..1601747	-	789	WP_262607377.1	exotoxin	-
MUA10_RS07700 (MUA10_07695)	1602193..1602561	-	369	WP_135831022.1	hypothetical protein	-
MUA10_RS07705 (MUA10_07700)	1602656..1602943	-	288	WP_001040260.1	hypothetical protein	-
MUA10_RS07710 (MUA10_07705)	1602990..1603142	-	153	WP_001153680.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sea	1594539..1657224	62685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6848.50 Da
• Isoelectric Point: 10.6777

>T240340 WP_078061146.1 NZ_CP094778:c1600758-1600582 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T240340 NZ_LS992192:4422357-4422614 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT240340 NZ_CP094778:1600467-1600523 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin