Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2474987..2475171 Replicon chromosome
Accession NZ_CP094775
Organism Staphylococcus aureus strain IVB6191

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA69_RS12425 Protein ID WP_000482647.1
Coordinates 2475064..2475171 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2474987..2475047 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA69_RS12410 (MUA69_12385) 2470441..2470608 - 168 WP_001789205.1 hypothetical protein -
MUA69_RS12415 (MUA69_12390) 2470839..2472572 - 1734 Protein_2400 ABC transporter ATP-binding protein/permease -
MUA69_RS12420 (MUA69_12395) 2472597..2474360 - 1764 WP_262538151.1 ABC transporter ATP-binding protein -
- 2474987..2475047 + 61 - - Antitoxin
MUA69_RS12425 (MUA69_12400) 2475064..2475171 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA69_RS12430 (MUA69_12405) 2475305..2475691 - 387 WP_000779353.1 flippase GtxA -
MUA69_RS12435 (MUA69_12410) 2475959..2477101 + 1143 WP_162636418.1 glycerate kinase -
MUA69_RS12440 (MUA69_12415) 2477161..2477820 + 660 WP_262538147.1 hypothetical protein -
MUA69_RS12445 (MUA69_12420) 2478002..2479213 + 1212 WP_001191923.1 multidrug effflux MFS transporter -
MUA69_RS12450 (MUA69_12425) 2479336..2479809 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240336 WP_000482647.1 NZ_CP094775:c2475171-2475064 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240336 NZ_LS992192:3811656-3811874 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT240336 NZ_CP094775:2474987-2475047 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References