240335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2449770..2450287 Replicon chromosome
Accession NZ_CP094775
Organism Staphylococcus aureus strain IVB6191

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag MUA69_RS12290 Protein ID WP_000113263.1
Coordinates 2449770..2450036 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA69_RS12295 Protein ID WP_000584499.1
Coordinates 2450036..2450287 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA69_RS12265 (MUA69_12240) 2444919..2445455 - 537 WP_262607697.1 GNAT family N-acetyltransferase -
MUA69_RS12270 (MUA69_12245) 2445978..2446802 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA69_RS12275 (MUA69_12250) 2447005..2447187 - 183 WP_000079140.1 hypothetical protein -
MUA69_RS12280 (MUA69_12255) 2447274..2447741 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA69_RS12285 (MUA69_12260) 2447927..2449477 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA69_RS12290 (MUA69_12265) 2449770..2450036 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
MUA69_RS12295 (MUA69_12270) 2450036..2450287 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA69_RS12300 (MUA69_12275) 2450451..2450552 - 102 Protein_2377 hypothetical protein -
MUA69_RS12305 (MUA69_12280) 2450559..2451158 - 600 WP_262607698.1 DsbA family protein -
MUA69_RS12310 (MUA69_12285) 2451177..2451539 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA69_RS12315 (MUA69_12290) 2451794..2453044 + 1251 Protein_2380 FemA/FemB family glycyltransferase FmhA -
MUA69_RS12320 (MUA69_12295) 2453141..2453872 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA69_RS12325 (MUA69_12300) 2453869..2454588 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T240335 WP_000113263.1 NZ_CP094775:c2450036-2449770 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240335 NZ_LS992192:c3782702-3782400 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240335 WP_000584499.1 NZ_CP094775:c2450287-2450036 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240335 NZ_LS992192:c3782364-3782023 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References