Detailed information of TA system TA240329

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1840948..1841128
• Replicon: chromosome
• Accession: NZ_CP094775
• Organism: Staphylococcus aureus strain IVB6191

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA69_RS08920
• Protein ID: WP_001801861.1
• Coordinates: 1840948..1841043 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1841071..1841128 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA69_RS08890 (MUA69_08870)	1836018..1836590	+	573	WP_000414222.1	hypothetical protein	-
MUA69_RS08895 (MUA69_08875)	1836966..1837565	+	600	WP_262607570.1	ATP-binding cassette domain-containing protein	-
MUA69_RS08900 (MUA69_08880)	1838606..1838791	-	186	WP_000809858.1	hypothetical protein	-
MUA69_RS08905 (MUA69_08885)	1838793..1838969	-	177	WP_000375476.1	hypothetical protein	-
MUA69_RS08910 (MUA69_08890)	1838980..1839363	-	384	WP_000070811.1	hypothetical protein	-
MUA69_RS08915 (MUA69_08895)	1840050..1840496	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
MUA69_RS08920 (MUA69_08900)	1840948..1841043	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1841071..1841128	-	58	-	-	Antitoxin
MUA69_RS08925 (MUA69_08905)	1841166..1841267	+	102	WP_001791232.1	hypothetical protein	-
MUA69_RS08930 (MUA69_08910)	1841305..1841421	-	117	Protein_1756	transposase	-
MUA69_RS08935 (MUA69_08915)	1841929..1846038	-	4110	Protein_1757	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1832638..1888480	55842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240329 WP_001801861.1 NZ_CP094775:1840948-1841043 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240329 NZ_LS992192:1932558-1932809 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240329 NZ_CP094775:c1841128-1841071 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin