Detailed information of TA system TA240325

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2503291..2503475
• Replicon: chromosome
• Accession: NZ_CP094773
• Organism: Staphylococcus aureus strain IVB6195

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA47_RS12440
• Protein ID: WP_000482647.1
• Coordinates: 2503368..2503475 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2503291..2503351 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA47_RS12425	2498745..2498912	-	168	WP_031901225.1	hypothetical protein	-
MUA47_RS12430	2499143..2500876	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUA47_RS12435	2500901..2502664	-	1764	WP_262634678.1	ABC transporter ATP-binding protein	-
-	2503291..2503351	+	61	-	-	Antitoxin
MUA47_RS12440	2503368..2503475	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA47_RS12445	2503609..2503995	-	387	WP_000779350.1	flippase GtxA	-
MUA47_RS12450	2504263..2505405	+	1143	WP_001176867.1	glycerate kinase	-
MUA47_RS12455	2505465..2506124	+	660	WP_000831298.1	membrane protein	-
MUA47_RS12460	2506307..2507518	+	1212	WP_250425584.1	multidrug effflux MFS transporter	-
MUA47_RS12465	2507641..2508114	-	474	WP_262634679.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB	2479853..2503995	24142

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240325 WP_000482647.1 NZ_CP094773:c2503475-2503368 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240325 NZ_LS992192:c600636-600172 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240325 NZ_CP094773:2503291-2503351 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin