Detailed information of TA system TA240324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2476482..2476999
• Replicon: chromosome
• Accession: NZ_CP094773
• Organism: Staphylococcus aureus strain IVB6195

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA47_RS12295
• Protein ID: WP_000113259.1
• Coordinates: 2476482..2476748 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA47_RS12300
• Protein ID: WP_000584500.1
• Coordinates: 2476748..2476999 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA47_RS12265 (2471652)	2471652..2472188	-	537	WP_000185899.1	GNAT family N-acetyltransferase	-
MUA47_RS12270 (2472688)	2472688..2473512	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
MUA47_RS12275 (2473715)	2473715..2473897	-	183	WP_000079140.1	hypothetical protein	-
MUA47_RS12280 (2473984)	2473984..2474451	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
MUA47_RS12285 (2474637)	2474637..2476187	-	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA47_RS12290 (2476376)	2476376..2476465	-	90	Protein_2375	hypothetical protein	-
MUA47_RS12295 (2476482)	2476482..2476748	-	267	WP_000113259.1	Txe/YoeB family addiction module toxin	Toxin
MUA47_RS12300 (2476748)	2476748..2476999	-	252	WP_000584500.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA47_RS12305 (2477163)	2477163..2477243	-	81	WP_224085678.1	hypothetical protein	-
MUA47_RS12310 (2477271)	2477271..2477870	-	600	WP_000162810.1	DsbA family protein	-
MUA47_RS12315 (2477889)	2477889..2478251	-	363	WP_000819848.1	DUF4467 domain-containing protein	-
MUA47_RS12320 (2478506)	2478506..2479756	+	1251	WP_262633502.1	FemA/FemB family glycyltransferase FmhA	-
MUA47_RS12325 (2479853)	2479853..2480584	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MUA47_RS12330 (2480581)	2480581..2481300	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10464.08 Da
• Isoelectric Point: 10.2538

>T240324 WP_000113259.1 NZ_CP094773:c2476748-2476482 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240324 NZ_LS992192:289193-289720 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9419.58 Da
• Isoelectric Point: 4.3407

>AT240324 WP_000584500.1 NZ_CP094773:c2476999-2476748 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT240324 NZ_LS992192:288920-289186 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA