Detailed information of TA system TA240311

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 371526..371833
• Replicon: chromosome
• Accession: NZ_CP094773
• Organism: Staphylococcus aureus strain IVB6195

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA47_RS01665
• Protein ID: WP_072357969.1
• Coordinates: 371526..371702 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	371692..371833 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA47_RS01635	366800..367090	+	291	WP_000179864.1	hypothetical protein	-
MUA47_RS01640	367106..369016	+	1911	WP_250406127.1	hypothetical protein	-
MUA47_RS01645	369016..370482	+	1467	WP_250425823.1	BppU family phage baseplate upper protein	-
MUA47_RS01650	370482..370871	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA47_RS01655	370864..371028	+	165	WP_000916021.1	XkdX family protein	-
MUA47_RS01660	371074..371373	+	300	WP_000466774.1	DUF2951 family protein	-
MUA47_RS01665	371526..371702	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	371692..371833	-	142	-	-	Antitoxin
MUA47_RS01675	371913..372215	+	303	WP_000339141.1	phage holin	-
MUA47_RS01680	372226..373680	+	1455	WP_250425827.1	N-acetylmuramoyl-L-alanine amidase	-
MUA47_RS01685	374776..375162	+	387	WP_228480554.1	hypothetical protein	-
MUA47_RS01690	375722..376549	-	828	WP_262634724.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	329007..373680	44673

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T240311 WP_072357969.1 NZ_CP094773:371526-371702 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240311 NZ_LS992190:c4205213-4204929 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Nucleotide

• Length: 142 bp

>AT240311 NZ_CP094773:c371833-371692 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin