Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2529650..2530173 Replicon chromosome
Accession NZ_CP094772
Organism Staphylococcus aureus strain IVB6196

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA50_RS12715 Protein ID WP_000074047.1
Coordinates 2529650..2529916 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA50_RS12720 Protein ID WP_000587617.1
Coordinates 2529916..2530173 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA50_RS12695 (2524861) 2524861..2526048 - 1188 WP_000026190.1 MFS transporter -
MUA50_RS12700 (2526442) 2526442..2527218 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
MUA50_RS12705 (2527211) 2527211..2527873 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA50_RS12710 (2528219) 2528219..2529295 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA50_RS12715 (2529650) 2529650..2529916 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA50_RS12720 (2529916) 2529916..2530173 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA50_RS12725 (2530533) 2530533..2530988 + 456 WP_000732090.1 YehR family lipoprotein -
MUA50_RS12730 (2531156) 2531156..2532733 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA50_RS12735 (2532929) 2532929..2533678 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA50_RS12740 (2533902) 2533902..2535095 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240307 WP_000074047.1 NZ_CP094772:c2529916-2529650 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240307 NZ_LS992190:2873867-2873974 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240307 WP_000587617.1 NZ_CP094772:c2530173-2529916 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240307 NZ_LS992190:c2873810-2873755 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References