Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2473036..2473553 | Replicon | chromosome |
| Accession | NZ_CP094772 | ||
| Organism | Staphylococcus aureus strain IVB6196 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A170NWK0 |
| Locus tag | MUA50_RS12440 | Protein ID | WP_000251928.1 |
| Coordinates | 2473036..2473302 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A166LMC5 |
| Locus tag | MUA50_RS12445 | Protein ID | WP_000584497.1 |
| Coordinates | 2473302..2473553 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA50_RS12415 (2468243) | 2468243..2468779 | - | 537 | WP_000024292.1 | GNAT family N-acetyltransferase | - |
| MUA50_RS12420 (2469247) | 2469247..2470071 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| MUA50_RS12425 (2470274) | 2470274..2470456 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MUA50_RS12430 (2470543) | 2470543..2471010 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| MUA50_RS12435 (2471196) | 2471196..2472743 | - | 1548 | WP_000727771.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUA50_RS12440 (2473036) | 2473036..2473302 | - | 267 | WP_000251928.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA50_RS12445 (2473302) | 2473302..2473553 | - | 252 | WP_000584497.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA50_RS12450 (2473717) | 2473717..2473817 | - | 101 | Protein_2410 | hypothetical protein | - |
| MUA50_RS12455 (2473824) | 2473824..2474423 | - | 600 | WP_000162804.1 | DsbA family protein | - |
| MUA50_RS12460 (2474442) | 2474442..2474804 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUA50_RS12465 (2475059) | 2475059..2476309 | + | 1251 | WP_262540029.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUA50_RS12470 (2476406) | 2476406..2477137 | - | 732 | WP_000615467.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA50_RS12475 (2477134) | 2477134..2477853 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10465.06 Da Isoelectric Point: 10.1628
>T240304 WP_000251928.1 NZ_CP094772:c2473302-2473036 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240304 NZ_LS992190:c1971644-1971270 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9401.54 Da Isoelectric Point: 4.3407
>AT240304 WP_000584497.1 NZ_CP094772:c2473553-2473302 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
Download Length: 252 bp
>AT240304 NZ_LS992190:c1972101-1971733 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A170NWK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A166LMC5 |