Detailed information of TA system TA240296

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1402667..1402997
• Replicon: chromosome
• Accession: NZ_CP094772
• Organism: Staphylococcus aureus strain IVB6196

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA50_RS07245
• Protein ID: WP_078061146.1
• Coordinates: 1402667..1402843 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1402895..1402997 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA50_RS07225	1400283..1400435	+	153	WP_001153680.1	hypothetical protein	-
MUA50_RS07230	1400482..1400769	+	288	WP_001040260.1	hypothetical protein	-
MUA50_RS07235	1400864..1401232	+	369	WP_135831022.1	hypothetical protein	-
MUA50_RS07240	1401687..1402466	+	780	WP_000746437.1	exotoxin	-
MUA50_RS07245	1402667..1402843	+	177	WP_078061146.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1402895..1402997	-	103	-	-	Antitoxin
MUA50_RS07255	1403047..1403301	+	255	WP_045178738.1	phage holin	-
MUA50_RS07260	1403313..1404068	+	756	WP_045178739.1	CHAP domain-containing protein	-
MUA50_RS07265	1404256..1404747	+	492	WP_045178740.1	staphylokinase	-
MUA50_RS07270	1405558..1405773	+	216	WP_000126130.1	hypothetical protein	-
MUA50_RS07275	1405863..1406768	+	906	WP_000913238.1	DUF1672 domain-containing protein	-
MUA50_RS07280	1406826..1407740	+	915	WP_000476887.1	DUF1672 domain-containing protein	-
MUA50_RS07285	1407733..1407879	+	147	WP_001033756.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6848.50 Da
• Isoelectric Point: 10.6777

>T240296 WP_078061146.1 NZ_CP094772:1402667-1402843 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T240296 NZ_LS992190:358548-359075 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Nucleotide

• Length: 103 bp

>AT240296 NZ_CP094772:c1402997-1402895 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCG
TTAAAAAGACGGTGACTATTTTA

Structures

Antitoxin