Detailed information of TA system TA240293

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1040344..1040524
• Replicon: chromosome
• Accession: NZ_CP094772
• Organism: Staphylococcus aureus strain IVB6196

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA50_RS05345
• Protein ID: WP_001801861.1
• Coordinates: 1040429..1040524 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1040344..1040401 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA50_RS05320	1035757..1038177	-	2421	WP_262540121.1	polysaccharide lyase 8 family protein	-
MUA50_RS05325	1038702..1039144	+	443	Protein_1004	DUF1433 domain-containing protein	-
MUA50_RS05330	1039144..1039587	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA50_RS05335	1039587..1040030	+	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA50_RS05340	1040205..1040306	-	102	WP_001791232.1	hypothetical protein	-
-	1040344..1040401	+	58	-	-	Antitoxin
MUA50_RS05345	1040429..1040524	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
MUA50_RS05350	1040975..1041421	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA50_RS05355	1041614..1042183	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA50_RS05360	1042183..1043550	+	1368	WP_001093574.1	FRG domain-containing protein	-
MUA50_RS05365	1043699..1044271	-	573	WP_000414222.1	hypothetical protein	-
MUA50_RS05370	1044369..1044713	-	345	WP_000627550.1	DUF3969 family protein	-
MUA50_RS05375	1044754..1045380	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240293 WP_001801861.1 NZ_CP094772:c1040524-1040429 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240293 NZ_LS992190:c46337-45960 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240293 NZ_CP094772:1040344-1040401 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin