Detailed information of TA system TA240287

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 356581..356919
• Replicon: chromosome
• Accession: NZ_CP094772
• Organism: Staphylococcus aureus strain IVB6196

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA50_RS01645
• Protein ID: WP_072357969.1
• Coordinates: 356581..356757 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	356745..356919 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA50_RS01615	351855..352145	+	291	WP_000179864.1	hypothetical protein	-
MUA50_RS01620	352161..354071	+	1911	WP_262540076.1	hypothetical protein	-
MUA50_RS01625	354071..355537	+	1467	WP_045179073.1	BppU family phage baseplate upper protein	-
MUA50_RS01630	355537..355926	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA50_RS01635	355919..356083	+	165	WP_262516148.1	XkdX family protein	-
MUA50_RS01640	356129..356428	+	300	WP_000466774.1	DUF2951 family protein	-
MUA50_RS01645	356581..356757	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	356745..356919	-	175	-	-	Antitoxin
MUA50_RS01655	357201..358847	+	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
MUA50_RS01665	360560..360862	+	303	WP_000339141.1	phage holin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	314061..366468	52407

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T240287 WP_072357969.1 NZ_CP094772:356581-356757 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240287 NZ_LS992186:c121134-120928 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT240287 NZ_CP094772:c356919-356745 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin