Detailed information of TA system TA240285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2491382..2491566
• Replicon: chromosome
• Accession: NZ_CP094770
• Organism: Staphylococcus aureus strain IVB6201

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA35_RS12535
• Protein ID: WP_000482647.1
• Coordinates: 2491459..2491566 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2491382..2491442 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA35_RS12520 (MUA35_12485)	2486836..2487003	-	168	WP_001789205.1	hypothetical protein	-
MUA35_RS12525 (MUA35_12490)	2487234..2488967	-	1734	Protein_2423	ABC transporter ATP-binding protein/permease	-
MUA35_RS12530 (MUA35_12495)	2488992..2490755	-	1764	WP_262538151.1	ABC transporter ATP-binding protein	-
-	2491382..2491442	+	61	-	-	Antitoxin
MUA35_RS12535 (MUA35_12500)	2491459..2491566	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA35_RS12540 (MUA35_12505)	2491700..2492086	-	387	WP_000779353.1	flippase GtxA	-
MUA35_RS12545 (MUA35_12510)	2492354..2493496	+	1143	WP_162636418.1	glycerate kinase	-
MUA35_RS12550 (MUA35_12515)	2493556..2494215	+	660	WP_262538147.1	hypothetical protein	-
MUA35_RS12555 (MUA35_12520)	2494397..2495608	+	1212	WP_001191923.1	multidrug effflux MFS transporter	-
MUA35_RS12560 (MUA35_12525)	2495731..2496204	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240285 WP_000482647.1 NZ_CP094770:c2491566-2491459 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240285 NZ_LS992186:50405-50785 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT240285 NZ_CP094770:2491382-2491442 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin