240284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2466166..2466683 Replicon chromosome
Accession NZ_CP094770
Organism Staphylococcus aureus strain IVB6201

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag MUA35_RS12400 Protein ID WP_000113263.1
Coordinates 2466166..2466432 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA35_RS12405 Protein ID WP_000584499.1
Coordinates 2466432..2466683 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA35_RS12375 (MUA35_12340) 2461318..2461854 - 537 WP_262607697.1 GNAT family N-acetyltransferase -
MUA35_RS12380 (MUA35_12345) 2462377..2463201 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA35_RS12385 (MUA35_12350) 2463404..2463586 - 183 WP_000079140.1 hypothetical protein -
MUA35_RS12390 (MUA35_12355) 2463673..2464140 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA35_RS12395 (MUA35_12360) 2464326..2465873 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA35_RS12400 (MUA35_12365) 2466166..2466432 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
MUA35_RS12405 (MUA35_12370) 2466432..2466683 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA35_RS12410 (MUA35_12375) 2466847..2466948 - 102 Protein_2400 hypothetical protein -
MUA35_RS12415 (MUA35_12380) 2466955..2467554 - 600 WP_262607698.1 DsbA family protein -
MUA35_RS12420 (MUA35_12385) 2467573..2467935 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA35_RS12425 (MUA35_12390) 2468190..2469440 + 1251 Protein_2403 FemA/FemB family glycyltransferase FmhA -
MUA35_RS12430 (MUA35_12395) 2469537..2470268 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA35_RS12435 (MUA35_12400) 2470265..2470984 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T240284 WP_000113263.1 NZ_CP094770:c2466432-2466166 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240284 NZ_LS992186:36990-37406 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240284 WP_000584499.1 NZ_CP094770:c2466683-2466432 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240284 NZ_LS992186:36763-36993 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References