Detailed information of TA system TA240278

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1857522..1857702
• Replicon: chromosome
• Accession: NZ_CP094770
• Organism: Staphylococcus aureus strain IVB6201

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA35_RS09030
• Protein ID: WP_001801861.1
• Coordinates: 1857522..1857617 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1857645..1857702 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA35_RS09000 (MUA35_08975)	1852592..1853164	+	573	WP_000414222.1	hypothetical protein	-
MUA35_RS09005 (MUA35_08980)	1853540..1854139	+	600	WP_262607570.1	ATP-binding cassette domain-containing protein	-
MUA35_RS09010 (MUA35_08985)	1855180..1855365	-	186	WP_000809858.1	hypothetical protein	-
MUA35_RS09015 (MUA35_08990)	1855367..1855543	-	177	WP_000375476.1	hypothetical protein	-
MUA35_RS09020 (MUA35_08995)	1855554..1855937	-	384	WP_000070811.1	hypothetical protein	-
MUA35_RS09025 (MUA35_09000)	1856624..1857070	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
MUA35_RS09030 (MUA35_09005)	1857522..1857617	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1857645..1857702	-	58	-	-	Antitoxin
MUA35_RS09035 (MUA35_09010)	1857740..1857841	+	102	WP_001791232.1	hypothetical protein	-
MUA35_RS09040 (MUA35_09015)	1857879..1857995	-	117	Protein_1778	transposase	-
MUA35_RS09045 (MUA35_09020)	1858503..1862612	-	4110	Protein_1779	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240278 WP_001801861.1 NZ_CP094770:1857522-1857617 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240278 NZ_LS992185:c3952904-3952569 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT240278 NZ_CP094770:c1857702-1857645 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin