240268

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 378755..379272 Replicon chromosome
Accession NZ_CP094768
Organism Staphylococcus aureus strain IVB6202

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag MUA94_RS01765 Protein ID WP_000113263.1
Coordinates 379006..379272 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA94_RS01760 Protein ID WP_000584499.1
Coordinates 378755..379006 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA94_RS01730 (MUA94_01725) 374454..375173 + 720 WP_000479576.1 amino acid ABC transporter permease -
MUA94_RS01735 (MUA94_01730) 375170..375901 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA94_RS01740 (MUA94_01735) 375998..377248 - 1251 Protein_345 FemA/FemB family glycyltransferase FmhA -
MUA94_RS01745 (MUA94_01740) 377503..377865 + 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA94_RS01750 (MUA94_01745) 377884..378483 + 600 WP_262538168.1 DsbA family protein -
MUA94_RS01755 (MUA94_01750) 378490..378591 + 102 Protein_348 hypothetical protein -
MUA94_RS01760 (MUA94_01755) 378755..379006 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA94_RS01765 (MUA94_01760) 379006..379272 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
MUA94_RS01770 (MUA94_01765) 379565..381115 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA94_RS01775 (MUA94_01770) 381301..381768 + 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA94_RS01780 (MUA94_01775) 381855..382037 + 183 WP_000079140.1 hypothetical protein -
MUA94_RS01785 (MUA94_01780) 382240..383064 + 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA94_RS01790 (MUA94_01785) 383587..384123 + 537 WP_262538170.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T240268 WP_000113263.1 NZ_CP094768:379006-379272 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240268 NZ_LS992185:c2208254-2208147 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240268 WP_000584499.1 NZ_CP094768:378755-379006 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240268 NZ_LS992185:2208302-2208368 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References