Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2589197..2589381 Replicon chromosome
Accession NZ_CP094765
Organism Staphylococcus aureus strain IVB6215

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA45_RS13110 Protein ID WP_000482647.1
Coordinates 2589274..2589381 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2589197..2589257 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA45_RS13095 (MUA45_13090) 2584707..2584874 - 168 Protein_2536 hypothetical protein -
MUA45_RS13100 (MUA45_13095) 2585105..2586838 - 1734 WP_000486505.1 ABC transporter ATP-binding protein -
MUA45_RS13105 (MUA45_13100) 2586863..2588626 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2589197..2589257 + 61 - - Antitoxin
MUA45_RS13110 (MUA45_13105) 2589274..2589381 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA45_RS13115 (MUA45_13110) 2589515..2589901 - 387 WP_000779351.1 flippase GtxA -
MUA45_RS13120 (MUA45_13115) 2590169..2591311 + 1143 WP_262633680.1 glycerate kinase -
MUA45_RS13125 (MUA45_13120) 2591371..2592030 + 660 WP_000831298.1 membrane protein -
MUA45_RS13130 (MUA45_13125) 2592212..2593423 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
MUA45_RS13135 (MUA45_13130) 2593546..2594019 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240263 WP_000482647.1 NZ_CP094765:c2589381-2589274 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240263 NZ_LS992185:c1026161-1025883 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 61 bp

>AT240263 NZ_CP094765:2589197-2589257 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References