Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2561976..2562493 Replicon chromosome
Accession NZ_CP094765
Organism Staphylococcus aureus strain IVB6215

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA45_RS12970 Protein ID WP_000251928.1
Coordinates 2561976..2562242 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA45_RS12975 Protein ID WP_000584497.1
Coordinates 2562242..2562493 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA45_RS12945 (MUA45_12940) 2557183..2557719 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA45_RS12950 (MUA45_12945) 2558187..2559011 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA45_RS12955 (MUA45_12950) 2559214..2559396 - 183 WP_000079140.1 hypothetical protein -
MUA45_RS12960 (MUA45_12955) 2559483..2559950 - 468 WP_250396336.1 SRPBCC domain-containing protein -
MUA45_RS12965 (MUA45_12960) 2560136..2561683 - 1548 WP_045179540.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA45_RS12970 (MUA45_12965) 2561976..2562242 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA45_RS12975 (MUA45_12970) 2562242..2562493 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA45_RS12980 (MUA45_12975) 2562657..2562757 - 101 Protein_2513 hypothetical protein -
MUA45_RS12985 (MUA45_12980) 2562764..2563363 - 600 WP_000162804.1 DsbA family protein -
MUA45_RS12990 (MUA45_12985) 2563382..2563744 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA45_RS12995 (MUA45_12990) 2563999..2565249 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
MUA45_RS13000 (MUA45_12995) 2565346..2566077 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA45_RS13005 (MUA45_13000) 2566074..2566793 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240262 WP_000251928.1 NZ_CP094765:c2562242-2561976 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240262 NZ_LS992185:691919-692206 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240262 WP_000584497.1 NZ_CP094765:c2562493-2562242 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240262 NZ_LS992185:692193-692495 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References