Detailed information of TA system TA240262

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2561976..2562493
• Replicon: chromosome
• Accession: NZ_CP094765
• Organism: Staphylococcus aureus strain IVB6215

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A170NWK0
• Locus tag: MUA45_RS12970
• Protein ID: WP_000251928.1
• Coordinates: 2561976..2562242 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A166LMC5
• Locus tag: MUA45_RS12975
• Protein ID: WP_000584497.1
• Coordinates: 2562242..2562493 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA45_RS12945 (MUA45_12940)	2557183..2557719	-	537	WP_000024292.1	GNAT family N-acetyltransferase	-
MUA45_RS12950 (MUA45_12945)	2558187..2559011	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
MUA45_RS12955 (MUA45_12950)	2559214..2559396	-	183	WP_000079140.1	hypothetical protein	-
MUA45_RS12960 (MUA45_12955)	2559483..2559950	-	468	WP_250396336.1	SRPBCC domain-containing protein	-
MUA45_RS12965 (MUA45_12960)	2560136..2561683	-	1548	WP_045179540.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA45_RS12970 (MUA45_12965)	2561976..2562242	-	267	WP_000251928.1	Txe/YoeB family addiction module toxin	Toxin
MUA45_RS12975 (MUA45_12970)	2562242..2562493	-	252	WP_000584497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA45_RS12980 (MUA45_12975)	2562657..2562757	-	101	Protein_2513	hypothetical protein	-
MUA45_RS12985 (MUA45_12980)	2562764..2563363	-	600	WP_000162804.1	DsbA family protein	-
MUA45_RS12990 (MUA45_12985)	2563382..2563744	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MUA45_RS12995 (MUA45_12990)	2563999..2565249	+	1251	WP_001012237.1	FemA/FemB family glycyltransferase FmhA	-
MUA45_RS13000 (MUA45_12995)	2565346..2566077	-	732	WP_000615467.1	amino acid ABC transporter ATP-binding protein	-
MUA45_RS13005 (MUA45_13000)	2566074..2566793	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.06 Da
• Isoelectric Point: 10.1628

>T240262 WP_000251928.1 NZ_CP094765:c2562242-2561976 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240262 NZ_LS992185:691919-692206 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9401.54 Da
• Isoelectric Point: 4.3407

>AT240262 WP_000584497.1 NZ_CP094765:c2562493-2562242 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT240262 NZ_LS992185:692193-692495 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: A0A170NWK0

Antitoxin

• AlphaFold DB: A0A166LMC5