Detailed information of TA system TA240257

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2009767..2009947
• Replicon: chromosome
• Accession: NZ_CP094765
• Organism: Staphylococcus aureus strain IVB6215

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA45_RS09990
• Protein ID: WP_001801861.1
• Coordinates: 2009767..2009862 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2009890..2009947 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA45_RS09965 (MUA45_09960)	2004815..2006182	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA45_RS09970 (MUA45_09965)	2006182..2006613	-	432	WP_262518258.1	ImmA/IrrE family metallo-endopeptidase	-
MUA45_RS09975 (MUA45_09970)	2006606..2008252	-	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
MUA45_RS09980 (MUA45_09975)	2008495..2008677	-	183	WP_262518259.1	hypothetical protein	-
MUA45_RS09985 (MUA45_09980)	2008870..2009316	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA45_RS09990 (MUA45_09985)	2009767..2009862	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2009890..2009947	-	58	-	-	Antitoxin
MUA45_RS09995 (MUA45_09990)	2009985..2010086	+	102	WP_001791232.1	hypothetical protein	-
MUA45_RS10000 (MUA45_09995)	2010261..2010704	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA45_RS10005 (MUA45_10000)	2010704..2011147	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA45_RS10010 (MUA45_10005)	2011147..2011589	-	443	Protein_1971	DUF1433 domain-containing protein	-
MUA45_RS10015 (MUA45_10010)	2012114..2014534	+	2421	WP_252559462.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2006606..2008252	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240257 WP_001801861.1 NZ_CP094765:2009767-2009862 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240257 NZ_LS992183:c4833165-4832791 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240257 NZ_CP094765:c2009947-2009890 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin