Detailed information of TA system TA240254

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1642957..1643248
• Replicon: chromosome
• Accession: NZ_CP094765
• Organism: Staphylococcus aureus strain IVB6215

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MUA45_RS08050
• Protein ID: WP_252559492.1
• Coordinates: 1643072..1643248 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1642957..1643013 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA45_RS08010 (MUA45_08005)	1638032..1638178	-	147	WP_001033756.1	hypothetical protein	-
MUA45_RS08015 (MUA45_08010)	1638171..1639085	-	915	WP_000476887.1	DUF1672 domain-containing protein	-
MUA45_RS08020 (MUA45_08015)	1639143..1640048	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
MUA45_RS08025 (MUA45_08020)	1640138..1640353	-	216	WP_262518166.1	hypothetical protein	-
MUA45_RS08030 (MUA45_08025)	1641166..1641657	-	492	WP_252559491.1	staphylokinase	-
MUA45_RS08035 (MUA45_08030)	1641847..1642602	-	756	WP_252559490.1	CHAP domain-containing protein	-
MUA45_RS08040 (MUA45_08035)	1642614..1642868	-	255	WP_238522769.1	phage holin	-
MUA45_RS08045 (MUA45_08040)	1642920..1643020	+	101	Protein_1579	hypothetical protein	-
-	1642957..1643013	+	57	-	-	Antitoxin
MUA45_RS08050 (MUA45_08045)	1643072..1643248	-	177	WP_252559492.1	type I toxin-antitoxin system toxin PepG1	Toxin
MUA45_RS08055 (MUA45_08050)	1643449..1644228	-	780	WP_262518171.1	exotoxin	-
MUA45_RS08060 (MUA45_08055)	1644683..1645057	-	375	WP_252559488.1	hypothetical protein	-
MUA45_RS08065 (MUA45_08060)	1645113..1645400	-	288	WP_162636283.1	hypothetical protein	-
MUA45_RS08070 (MUA45_08065)	1645446..1645598	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / sea / gnd	1640138..1709272	69134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6818.48 Da
• Isoelectric Point: 10.9678

>T240254 WP_252559492.1 NZ_CP094765:c1643248-1643072 [Staphylococcus aureus]
MDRWRLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T240254 NZ_LS992183:4480267-4480608 [Citrobacter freundii]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGCTGAGCTATATCTGTCGCCAGTGGCGGTGTGGCAAATGCTACTGAC
ACGCCTGCTGGAGCAGCACTATGGCCTGACACTGAACGACACGCCATTTAGTGATGAAACCGTTATTCAGGAACACATTG
ATGCCGGGATCATGCTGGCCGATGCTGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTTTACGGGCAAGACAGGCAACTGGCCTGTTGCGACAAAG
CCGTAACAACGCAGTACGGTGA

Antitoxin

Nucleotide

• Length: 57 bp

>AT240254 NZ_CP094765:1642957-1643013 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin