Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2529212..2529735 Replicon chromosome
Accession NZ_CP094763
Organism Staphylococcus aureus strain IVB6221

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA83_RS12580 Protein ID WP_000074048.1
Coordinates 2529212..2529478 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA83_RS12585 Protein ID WP_252549875.1
Coordinates 2529478..2529735 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA83_RS12560 (MUA83_12555) 2524431..2525618 - 1188 WP_000026189.1 MFS transporter -
MUA83_RS12565 (MUA83_12560) 2526013..2526789 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA83_RS12570 (MUA83_12565) 2526782..2527444 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
MUA83_RS12575 (MUA83_12570) 2527789..2528856 - 1068 WP_001076685.1 M42 family metallopeptidase -
MUA83_RS12580 (MUA83_12575) 2529212..2529478 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA83_RS12585 (MUA83_12580) 2529478..2529735 - 258 WP_252549875.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA83_RS12590 (MUA83_12585) 2530095..2530550 + 456 WP_262529168.1 DUF1307 domain-containing protein -
MUA83_RS12595 (MUA83_12590) 2530718..2532295 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
MUA83_RS12600 (MUA83_12595) 2532489..2533238 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA83_RS12605 (MUA83_12600) 2533462..2534655 - 1194 WP_252549877.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240252 WP_000074048.1 NZ_CP094763:c2529478-2529212 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240252 NZ_LS992183:c4245541-4245200 [Citrobacter freundii]
ATGAAAGCCTTTCCTGCAACAAATCAGCGGGTGGCGAAGCCATGCCCGTCGCCTGTGGCCGTCTGGCAGATGTTACTTAC
CCGTCTACTTGCGCAACACTATGGCCTGACGCTGAACGACACTCCATTCAATGATGAAAGTGTTATTCAGGAACATATCA
ACGCCGGTATCACATTAGCCGATGCCGTTAACTTTCTGGTGGAAAAGAACGAACTCGTGCGCATCGATCGCAGGGGATTT
AGCTGGCAGGAACAATCACCTTATCTCCGGGCTGTTGATATTCTGCGGGCGCGACAGGCCACCGGTCTGTTACGACAAAG
CCATAATCTTTTGACACGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.69 Da        Isoelectric Point: 4.0717

>AT240252 WP_252549875.1 NZ_CP094763:c2529735-2529478 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240252 NZ_LS992183:c4245921-4245577 [Citrobacter freundii]
ATGAAAAAGGACACAGCCAACGAAGTAATGGATACGTTGCAATGGGGACTAAAATGCGACATCACACCACATTTCGGGGC
CCGTCTGGCGCAGGAAGGCAACCGCCTGCATTACCTCGCCGATCGGGCCAGCATAATCGGCCAATTCAGCAAAGCAGATT
TACGCCATCTCAATCAGGCTTTTCCCTTGTTGATGAAGCACATGGAACTCATGCTCACCAGCGGAGAACTTAATCCCCGC
CACCAACACCGCGTTACGCTGTATGCGAAAAGATTAACCTGTGAAGTCGACACGCTCGGCTCTTGTGGCTACGTCTATAT
CGCCATTTACCCCACTCAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References