Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2497905..2498089 Replicon chromosome
Accession NZ_CP094763
Organism Staphylococcus aureus strain IVB6221

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA83_RS12440 Protein ID WP_000482647.1
Coordinates 2497982..2498089 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2497905..2497965 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA83_RS12425 (MUA83_12420) 2493359..2493526 - 168 WP_031927726.1 hypothetical protein -
MUA83_RS12430 (MUA83_12425) 2493757..2495490 - 1734 WP_000486497.1 ABC transporter ATP-binding protein -
MUA83_RS12435 (MUA83_12430) 2495515..2497278 - 1764 WP_262529161.1 ABC transporter ATP-binding protein -
- 2497905..2497965 + 61 - - Antitoxin
MUA83_RS12440 (MUA83_12435) 2497982..2498089 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA83_RS12445 (MUA83_12440) 2498223..2498609 - 387 WP_000779353.1 flippase GtxA -
MUA83_RS12450 (MUA83_12445) 2498877..2500019 + 1143 WP_001176867.1 glycerate kinase -
MUA83_RS12455 (MUA83_12450) 2500079..2500738 + 660 WP_000831298.1 membrane protein -
MUA83_RS12460 (MUA83_12455) 2500921..2502132 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
MUA83_RS12465 (MUA83_12460) 2502255..2502728 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240250 WP_000482647.1 NZ_CP094763:c2498089-2497982 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240250 NZ_LS992183:3634882-3635100 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGTCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT240250 NZ_CP094763:2497905-2497965 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References