Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2472532..2473049 | Replicon | chromosome |
| Accession | NZ_CP094763 | ||
| Organism | Staphylococcus aureus strain IVB6221 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | MUA83_RS12305 | Protein ID | WP_262529151.1 |
| Coordinates | 2472532..2472798 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MUA83_RS12310 | Protein ID | WP_000584499.1 |
| Coordinates | 2472798..2473049 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA83_RS12275 (MUA83_12270) | 2467684..2468220 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| MUA83_RS12280 (MUA83_12275) | 2468742..2469566 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| MUA83_RS12285 (MUA83_12280) | 2469769..2469951 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MUA83_RS12290 (MUA83_12285) | 2470038..2470505 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| MUA83_RS12295 (MUA83_12290) | 2470691..2472238 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUA83_RS12300 (MUA83_12295) | 2472417..2472497 | - | 81 | WP_225539491.1 | hypothetical protein | - |
| MUA83_RS12305 (MUA83_12300) | 2472532..2472798 | - | 267 | WP_262529151.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA83_RS12310 (MUA83_12305) | 2472798..2473049 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA83_RS12315 (MUA83_12310) | 2473214..2473294 | - | 81 | WP_225539489.1 | hypothetical protein | - |
| MUA83_RS12320 (MUA83_12315) | 2473322..2473921 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MUA83_RS12325 (MUA83_12320) | 2473940..2474302 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUA83_RS12330 (MUA83_12325) | 2474557..2475807 | + | 1251 | WP_262529152.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUA83_RS12335 (MUA83_12330) | 2475904..2476635 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA83_RS12340 (MUA83_12335) | 2476632..2477351 | - | 720 | WP_262529153.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10466.05 Da Isoelectric Point: 10.0373
>T240249 WP_262529151.1 NZ_CP094763:c2472798-2472532 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IVSCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IVSCKYHY
Download Length: 267 bp
>T240249 NZ_LS992183:c2949222-2948890 [Citrobacter freundii]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCAGCATCATTTAATAAGTTCACCCGGCTACCTGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCTCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTTGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCAGCATCATTTAATAAGTTCACCCGGCTACCTGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAACCCAGAACGATT
GATATGGGGGCTCGGAACGGTAAGTGTCTGGAACGTATACCCGAAGCTGTTGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTAAGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT240249 WP_000584499.1 NZ_CP094763:c2473049-2472798 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT240249 NZ_LS992183:c2949480-2949223 [Citrobacter freundii]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCTGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCTGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|