Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 345031..345445 Replicon chromosome
Accession NZ_CP094763
Organism Staphylococcus aureus strain IVB6221

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA83_RS01540 Protein ID WP_110166336.1
Coordinates 345031..345282 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA83_RS01545 Protein ID WP_000028424.1
Coordinates 345272..345445 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA83_RS01475 (MUA83_01475) 340195..340980 + 786 WP_262529385.1 ATP-binding protein -
MUA83_RS01480 (MUA83_01480) 340977..341137 + 161 Protein_293 hypothetical protein -
MUA83_RS01485 (MUA83_01485) 341150..341371 + 222 WP_001123695.1 DUF3269 family protein -
MUA83_RS01490 (MUA83_01490) 341382..341786 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA83_RS01495 (MUA83_01495) 341791..341976 + 186 WP_001187242.1 DUF3113 family protein -
MUA83_RS01500 (MUA83_01500) 341977..342594 + 618 WP_262529389.1 SA1788 family PVL leukocidin-associated protein -
MUA83_RS01505 (MUA83_01505) 342594..342851 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA83_RS01510 (MUA83_01510) 342854..343054 + 201 WP_252549766.1 hypothetical protein -
MUA83_RS01515 (MUA83_01515) 343051..343740 + 690 WP_262529392.1 SAM-dependent methyltransferase -
MUA83_RS01520 (MUA83_01520) 343754..343960 + 207 WP_252549760.1 hypothetical protein -
MUA83_RS01525 (MUA83_01525) 343988..344389 + 402 WP_252549758.1 hypothetical protein -
MUA83_RS01530 (MUA83_01530) 344386..344733 + 348 WP_252570428.1 YopX family protein -
MUA83_RS01535 (MUA83_01535) 344730..344951 + 222 Protein_304 hypothetical protein -
MUA83_RS01540 (MUA83_01540) 345031..345282 + 252 WP_110166336.1 DUF1024 family protein Toxin
MUA83_RS01545 (MUA83_01545) 345272..345445 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA83_RS01550 (MUA83_01550) 345446..345727 + 282 WP_000454994.1 hypothetical protein -
MUA83_RS01555 (MUA83_01555) 345728..345889 + 162 WP_000889683.1 hypothetical protein -
MUA83_RS01560 (MUA83_01560) 345904..346437 + 534 WP_025920701.1 dUTP diphosphatase -
MUA83_RS01565 (MUA83_01565) 346474..346680 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA83_RS01570 (MUA83_01570) 346677..346826 + 150 WP_000595265.1 transcriptional activator RinB -
MUA83_RS01575 (MUA83_01575) 346826..347026 + 201 WP_111761860.1 DUF1514 family protein -
MUA83_RS01580 (MUA83_01580) 347049..347510 + 462 WP_086037675.1 hypothetical protein -
MUA83_RS01585 (MUA83_01585) 347625..348077 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA83_RS01590 (MUA83_01590) 348093..348437 + 345 WP_000817289.1 HNH endonuclease -
MUA83_RS01595 (MUA83_01595) 348566..349036 + 471 WP_086037674.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 329363..370795 41432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T240238 WP_110166336.1 NZ_CP094763:345031-345282 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240238 NZ_LS992182:c72080-71664 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240238 WP_000028424.1 NZ_CP094763:345272-345445 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240238 NZ_LS992182:c72307-72077 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References