240237

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2443993..2444516 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA14_RS11995 Protein ID WP_000074048.1
Coordinates 2443993..2444259 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA14_RS12000 Protein ID WP_252549875.1
Coordinates 2444259..2444516 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS11975 (MUA14_11965) 2439212..2440399 - 1188 WP_000026189.1 MFS transporter -
MUA14_RS11980 (MUA14_11970) 2440794..2441570 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA14_RS11985 (MUA14_11975) 2441563..2442225 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
MUA14_RS11990 (MUA14_11980) 2442570..2443637 - 1068 WP_001076685.1 M42 family metallopeptidase -
MUA14_RS11995 (MUA14_11985) 2443993..2444259 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA14_RS12000 (MUA14_11990) 2444259..2444516 - 258 WP_252549875.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA14_RS12005 (MUA14_11995) 2444876..2445331 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA14_RS12010 (MUA14_12000) 2445499..2447076 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
MUA14_RS12015 (MUA14_12005) 2447270..2448019 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA14_RS12020 (MUA14_12010) 2448243..2449436 - 1194 WP_252549877.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240237 WP_000074048.1 NZ_CP094760:c2444259-2443993 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240237 NZ_LS992182:64938-65213 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.69 Da        Isoelectric Point: 4.0717

>AT240237 WP_252549875.1 NZ_CP094760:c2444516-2444259 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240237 NZ_LS992182:64654-64938 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References