240235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2412684..2412868 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA14_RS11855 Protein ID WP_000482647.1
Coordinates 2412761..2412868 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2412684..2412744 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS11840 (MUA14_11830) 2408138..2408305 - 168 WP_031927726.1 hypothetical protein -
MUA14_RS11845 (MUA14_11835) 2408536..2410269 - 1734 WP_000486497.1 ABC transporter ATP-binding protein -
MUA14_RS11850 (MUA14_11840) 2410294..2412057 - 1764 WP_252549861.1 ABC transporter ATP-binding protein -
- 2412684..2412744 + 61 - - Antitoxin
MUA14_RS11855 (MUA14_11845) 2412761..2412868 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA14_RS11860 (MUA14_11850) 2413002..2413388 - 387 WP_000779353.1 flippase GtxA -
MUA14_RS11865 (MUA14_11855) 2413656..2414798 + 1143 WP_252549863.1 glycerate kinase -
MUA14_RS11870 (MUA14_11860) 2414858..2415517 + 660 WP_262541395.1 hypothetical protein -
MUA14_RS11875 (MUA14_11865) 2415700..2416911 + 1212 WP_252549865.1 multidrug effflux MFS transporter -
MUA14_RS11880 (MUA14_11870) 2417034..2417507 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240235 WP_000482647.1 NZ_CP094760:c2412868-2412761 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240235 NZ_LS992181:c124156-123998 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 61 bp

>AT240235 NZ_CP094760:2412684-2412744 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References