240234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2387379..2387896 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA14_RS11720 Protein ID WP_000113260.1
Coordinates 2387379..2387645 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA14_RS11725 Protein ID WP_000584499.1
Coordinates 2387645..2387896 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS11690 (MUA14_11680) 2382476..2383012 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
MUA14_RS11695 (MUA14_11685) 2383589..2384413 - 825 WP_000594633.1 formate/nitrite transporter family protein -
MUA14_RS11700 (MUA14_11690) 2384616..2384798 - 183 WP_000079140.1 hypothetical protein -
MUA14_RS11705 (MUA14_11695) 2384885..2385352 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA14_RS11710 (MUA14_11700) 2385538..2387085 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA14_RS11715 (MUA14_11705) 2387264..2387344 - 81 WP_225539491.1 hypothetical protein -
MUA14_RS11720 (MUA14_11710) 2387379..2387645 - 267 WP_000113260.1 Txe/YoeB family addiction module toxin Toxin
MUA14_RS11725 (MUA14_11715) 2387645..2387896 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA14_RS11730 (MUA14_11720) 2388061..2388141 - 81 WP_225539489.1 hypothetical protein -
MUA14_RS11735 (MUA14_11725) 2388169..2388768 - 600 WP_000162810.1 DsbA family protein -
MUA14_RS11740 (MUA14_11730) 2388787..2389149 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA14_RS11745 (MUA14_11735) 2389404..2390654 + 1251 WP_262541390.1 FemA/FemB family glycyltransferase FmhA -
MUA14_RS11750 (MUA14_11740) 2390751..2391482 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA14_RS11755 (MUA14_11745) 2391479..2392198 - 720 WP_000479579.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.99 Da        Isoelectric Point: 10.0373

>T240234 WP_000113260.1 NZ_CP094760:c2387645-2387379 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240234 NZ_LS992181:c79125-78976 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240234 WP_000584499.1 NZ_CP094760:c2387896-2387645 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240234 NZ_LS992181:79173-79229 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References