240229

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 347589..348003 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA14_RS01565 Protein ID WP_252549750.1
Coordinates 347589..347840 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA14_RS01570 Protein ID WP_000028424.1
Coordinates 347830..348003 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS01500 (MUA14_01495) 342779..343564 + 786 WP_000443353.1 ATP-binding protein -
MUA14_RS01505 (MUA14_01500) 343561..343719 + 159 WP_000628833.1 hypothetical protein -
MUA14_RS01510 (MUA14_01505) 343732..343953 + 222 WP_001123695.1 DUF3269 family protein -
MUA14_RS01515 (MUA14_01510) 343964..344368 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA14_RS01520 (MUA14_01515) 344373..344558 + 186 WP_001187242.1 DUF3113 family protein -
MUA14_RS01525 (MUA14_01520) 344559..345176 + 618 WP_252549769.1 SA1788 family PVL leukocidin-associated protein -
MUA14_RS01530 (MUA14_01525) 345176..345433 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA14_RS01535 (MUA14_01530) 345436..345636 + 201 WP_252549766.1 hypothetical protein -
MUA14_RS01540 (MUA14_01535) 345633..346322 + 690 WP_252549763.1 N-6 DNA methylase -
MUA14_RS01545 (MUA14_01540) 346336..346542 + 207 WP_252549760.1 hypothetical protein -
MUA14_RS01550 (MUA14_01545) 346570..346971 + 402 WP_252549758.1 hypothetical protein -
MUA14_RS01555 (MUA14_01550) 346968..347315 + 348 WP_252549755.1 YopX family protein -
MUA14_RS01560 (MUA14_01555) 347312..347596 + 285 WP_061736435.1 hypothetical protein -
MUA14_RS01565 (MUA14_01560) 347589..347840 + 252 WP_252549750.1 DUF1024 family protein Toxin
MUA14_RS01570 (MUA14_01565) 347830..348003 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA14_RS01575 (MUA14_01570) 348004..348285 + 282 WP_000454994.1 hypothetical protein -
MUA14_RS01580 (MUA14_01575) 348286..348447 + 162 WP_000889683.1 hypothetical protein -
MUA14_RS01585 (MUA14_01580) 348462..348995 + 534 WP_025920701.1 dUTP diphosphatase -
MUA14_RS01590 (MUA14_01585) 349032..349238 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA14_RS01595 (MUA14_01590) 349235..349384 + 150 WP_031876778.1 transcriptional regulator -
MUA14_RS01600 (MUA14_01595) 349384..349584 + 201 WP_111761860.1 DUF1514 family protein -
MUA14_RS01605 (MUA14_01600) 349607..350068 + 462 WP_086037675.1 hypothetical protein -
MUA14_RS01610 (MUA14_01605) 350183..350635 + 453 WP_252549748.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA14_RS01615 (MUA14_01610) 350651..350995 + 345 WP_000817289.1 HNH endonuclease -
MUA14_RS01620 (MUA14_01615) 351124..351594 + 471 WP_086037674.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 331948..373353 41405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9417.29 Da        Isoelectric Point: 3.8567

>T240229 WP_252549750.1 NZ_CP094760:347589-347840 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240229 NZ_LS992180:c4409254-4408877 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240229 WP_000028424.1 NZ_CP094760:347830-348003 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240229 NZ_LS992180:c4409712-4409344 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References