240228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2483333..2483856 Replicon chromosome
Accession NZ_CP094758
Organism Staphylococcus aureus strain IVB6239

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA67_RS12505 Protein ID WP_000074048.1
Coordinates 2483333..2483599 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MUA67_RS12510 Protein ID WP_000587616.1
Coordinates 2483599..2483856 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA67_RS12485 (2478640) 2478640..2479827 - 1188 WP_000026189.1 MFS transporter -
MUA67_RS12490 (2480223) 2480223..2480999 - 777 WP_262610432.1 iron export ABC transporter permease subunit FetB -
MUA67_RS12495 (2480992) 2480992..2481654 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
MUA67_RS12500 (2481901) 2481901..2482977 - 1077 WP_262610434.1 M42 family metallopeptidase -
MUA67_RS12505 (2483333) 2483333..2483599 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA67_RS12510 (2483599) 2483599..2483856 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA67_RS12515 (2484215) 2484215..2484670 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA67_RS12520 (2484838) 2484838..2486415 - 1578 WP_262610436.1 FMN-binding glutamate synthase family protein -
MUA67_RS12525 (2486611) 2486611..2487360 + 750 WP_000072458.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA67_RS12530 (2487584) 2487584..2488777 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240228 WP_000074048.1 NZ_CP094758:c2483599-2483333 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240228 NZ_LS992180:4376255-4376512 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT240228 WP_000587616.1 NZ_CP094758:c2483856-2483599 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240228 NZ_LS992180:4376524-4377075 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References