Detailed information of TA system TA240227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2426767..2427284
• Replicon: chromosome
• Accession: NZ_CP094758
• Organism: Staphylococcus aureus strain IVB6239

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA67_RS12235
• Protein ID: WP_262610396.1
• Coordinates: 2426767..2427033 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA67_RS12240
• Protein ID: WP_262610397.1
• Coordinates: 2427033..2427284 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA67_RS12205 (2422193)	2422193..2422729	-	537	WP_262610393.1	GNAT family N-acetyltransferase	-
MUA67_RS12210 (2422962)	2422962..2423786	-	825	WP_262610394.1	formate/nitrite transporter family protein	-
MUA67_RS12215 (2424003)	2424003..2424185	-	183	WP_000230294.1	hypothetical protein	-
MUA67_RS12220 (2424269)	2424269..2424736	-	468	WP_262610395.1	SRPBCC domain-containing protein	-
MUA67_RS12225 (2424922)	2424922..2426472	-	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA67_RS12230 (2426661)	2426661..2426732	-	72	Protein_2362	hypothetical protein	-
MUA67_RS12235 (2426767)	2426767..2427033	-	267	WP_262610396.1	Txe/YoeB family addiction module toxin	Toxin
MUA67_RS12240 (2427033)	2427033..2427284	-	252	WP_262610397.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA67_RS12245 (2427448)	2427448..2427528	-	81	WP_223197974.1	hypothetical protein	-
MUA67_RS12250 (2427556)	2427556..2428155	-	600	WP_000162810.1	DsbA family protein	-
MUA67_RS12255 (2428174)	2428174..2428542	-	369	WP_160195056.1	DUF4467 domain-containing protein	-
MUA67_RS12260 (2428798)	2428798..2430048	+	1251	Protein_2368	FemA/FemB family glycyltransferase FmhA	-
MUA67_RS12265 (2430145)	2430145..2430876	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MUA67_RS12270 (2430873)	2430873..2431592	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10419.92 Da
• Isoelectric Point: 9.9143

>T240227 WP_262610396.1 NZ_CP094758:c2427033-2426767 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKIVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240227 NZ_LS992180:c4327394-4327107 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9445.66 Da
• Isoelectric Point: 4.3407

>AT240227 WP_262610397.1 NZ_CP094758:c2427284-2427033 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKIITKD
IDV

Nucleotide

• Length: 252 bp

>AT240227 NZ_LS992180:c4327120-4326818 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA