Detailed information of TA system TA240226

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2165433..2165650
• Replicon: chromosome
• Accession: NZ_CP094758
• Organism: Staphylococcus aureus strain IVB6239

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MUA67_RS10860
• Protein ID: WP_001802298.1
• Coordinates: 2165546..2165650 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2165433..2165488 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA67_RS10835	2161624..2162289	-	666	WP_262610233.1	SDR family oxidoreductase	-
MUA67_RS10840	2162441..2162761	+	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MUA67_RS10845	2162763..2163740	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
MUA67_RS10850	2164006..2165097	+	1092	WP_262610234.1	transcriptional regulator	-
-	2165433..2165488	+	56	-	-	Antitoxin
MUA67_RS10860	2165546..2165650	-	105	WP_001802298.1	hypothetical protein	Toxin
MUA67_RS10865	2165811..2166294	-	484	Protein_2098	recombinase family protein	-
MUA67_RS10870	2166337..2167473	-	1137	Protein_2099	SAP domain-containing protein	-
MUA67_RS10875	2167762..2167854	+	93	WP_262610235.1	hypothetical protein	-
MUA67_RS10880	2168143..2168327	+	185	Protein_2101	exotoxin	-
MUA67_RS10885	2168559..2169416	-	858	WP_262610236.1	HAD family hydrolase	-
MUA67_RS10890	2169484..2170266	-	783	WP_262610238.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T240226 WP_001802298.1 NZ_CP094758:c2165650-2165546 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T240226 NZ_LS992180:c4217116-4216832 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240226 NZ_CP094758:2165433-2165488 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin