Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1539742..1540156 | Replicon | chromosome |
| Accession | NZ_CP094758 | ||
| Organism | Staphylococcus aureus strain IVB6239 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MUA67_RS07470 | Protein ID | WP_262609845.1 |
| Coordinates | 1539905..1540156 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MUA67_RS07465 | Protein ID | WP_000028424.1 |
| Coordinates | 1539742..1539915 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA67_RS07410 (1535993) | 1535993..1536460 | - | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
| MUA67_RS07415 (1536588) | 1536588..1536932 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| MUA67_RS07420 (1536948) | 1536948..1537400 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| MUA67_RS07425 (1537515) | 1537515..1537985 | - | 471 | WP_262609843.1 | hypothetical protein | - |
| MUA67_RS07430 (1538008) | 1538008..1538208 | - | 201 | WP_045178577.1 | DUF1514 family protein | - |
| MUA67_RS07435 (1538208) | 1538208..1538357 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| MUA67_RS07440 (1538354) | 1538354..1538560 | - | 207 | WP_045178575.1 | DUF1381 domain-containing protein | - |
| MUA67_RS07445 (1538557) | 1538557..1538802 | - | 246 | WP_063815530.1 | hypothetical protein | - |
| MUA67_RS07450 (1538819) | 1538819..1538992 | - | 174 | WP_001209216.1 | hypothetical protein | - |
| MUA67_RS07455 (1539029) | 1539029..1539565 | - | 537 | WP_250396255.1 | dUTPase | - |
| MUA67_RS07460 (1539580) | 1539580..1539741 | - | 162 | WP_000889680.1 | hypothetical protein | - |
| MUA67_RS07465 (1539742) | 1539742..1539915 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| MUA67_RS07470 (1539905) | 1539905..1540156 | - | 252 | WP_262609845.1 | DUF1024 family protein | Toxin |
| MUA67_RS07475 (1540149) | 1540149..1540433 | - | 285 | WP_250396252.1 | hypothetical protein | - |
| MUA67_RS07480 (1540448) | 1540448..1540690 | - | 243 | WP_262609846.1 | phi PVL orf 51-like protein | - |
| MUA67_RS07485 (1540694) | 1540694..1541051 | - | 358 | Protein_1468 | hypothetical protein | - |
| MUA67_RS07490 (1541052) | 1541052..1541237 | - | 186 | WP_001187254.1 | DUF3113 family protein | - |
| MUA67_RS07495 (1541242) | 1541242..1541646 | - | 405 | WP_262609847.1 | DUF1064 domain-containing protein | - |
| MUA67_RS07500 (1541657) | 1541657..1541878 | - | 222 | WP_086037726.1 | DUF3269 family protein | - |
| MUA67_RS07505 (1541881) | 1541881..1542096 | - | 216 | WP_262609848.1 | hypothetical protein | - |
| MUA67_RS07510 (1542093) | 1542093..1543334 | - | 1242 | WP_234720012.1 | DnaB helicase C-terminal domain-containing protein | - |
| MUA67_RS07515 (1543331) | 1543331..1543687 | - | 357 | WP_001132243.1 | hypothetical protein | - |
| MUA67_RS07520 (1543687) | 1543687..1544442 | - | 756 | Protein_1475 | DnaD domain protein | - |
| MUA67_RS07525 (1544435) | 1544435..1545109 | - | 675 | WP_262609849.1 | putative HNHc nuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sak / gnd | 1513517..1578050 | 64533 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9474.38 Da Isoelectric Point: 3.8567
>T240220 WP_262609845.1 NZ_CP094758:c1540156-1539905 [Staphylococcus aureus]
MNNREQIEQSVISANAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMVSQVVYKYEEEQE
NEY
MNNREQIEQSVISANAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMVSQVVYKYEEEQE
NEY
Download Length: 252 bp
>T240220 NZ_LS992180:2268245-2268347 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT240220 WP_000028424.1 NZ_CP094758:c1539915-1539742 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT240220 NZ_LS992180:c2268385-2268117 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|