Detailed information of TA system TA240216

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1516335..1516552
• Replicon: chromosome
• Accession: NZ_CP094758
• Organism: Staphylococcus aureus strain IVB6239

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: MUA67_RS07315
• Protein ID: WP_000253687.1
• Coordinates: 1516445..1516552 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1516335..1516390 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA67_RS07285	1511561..1512106	-	546	WP_001186912.1	ECF transporter S component	-
MUA67_RS07290	1512495..1513426	-	932	Protein_1429	DUF1672 domain-containing protein	-
MUA67_RS07295	1513517..1513732	-	216	WP_000126130.1	hypothetical protein	-
MUA67_RS07300	1514544..1515035	-	492	WP_252559491.1	staphylokinase	-
MUA67_RS07305	1515225..1515980	-	756	WP_045178739.1	CHAP domain-containing protein	-
MUA67_RS07310	1515992..1516246	-	255	WP_238522769.1	phage holin	-
-	1516335..1516390	+	56	-	-	Antitoxin
MUA67_RS07315	1516445..1516552	-	108	WP_000253687.1	putative holin-like toxin	Toxin
MUA67_RS07320	1516787..1517083	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MUA67_RS07325	1517141..1517428	-	288	WP_001040261.1	hypothetical protein	-
MUA67_RS07330	1517475..1517627	-	153	WP_001153681.1	hypothetical protein	-
MUA67_RS07335	1517617..1521402	-	3786	WP_262609834.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / gnd	1513517..1578050	64533

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T240216 WP_000253687.1 NZ_CP094758:c1516552-1516445 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T240216 NZ_LS992180:1032348-1032755 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240216 NZ_CP094758:1516335-1516390 [Staphylococcus aureus]
AAAAAGGGCAACATGCGTAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin