Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2532611..2533134 Replicon chromosome
Accession NZ_CP094755
Organism Staphylococcus aureus strain IVB6242

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag MUA32_RS12700 Protein ID WP_000074047.1
Coordinates 2532611..2532877 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag MUA32_RS12705 Protein ID WP_000587617.1
Coordinates 2532877..2533134 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA32_RS12680 (2527821) 2527821..2529008 - 1188 WP_000026190.1 MFS transporter -
MUA32_RS12685 (2529402) 2529402..2530178 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
MUA32_RS12690 (2530171) 2530171..2530833 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
MUA32_RS12695 (2531179) 2531179..2532255 - 1077 WP_001076679.1 M42 family metallopeptidase -
MUA32_RS12700 (2532611) 2532611..2532877 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
MUA32_RS12705 (2532877) 2532877..2533134 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA32_RS12710 (2533494) 2533494..2533949 + 456 WP_000732090.1 YehR family lipoprotein -
MUA32_RS12715 (2534117) 2534117..2535694 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
MUA32_RS12720 (2535890) 2535890..2536639 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA32_RS12725 (2536863) 2536863..2538056 - 1194 WP_262516018.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T240208 WP_000074047.1 NZ_CP094755:c2532877-2532611 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240208 NZ_LS992180:c46337-45960 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT240208 WP_000587617.1 NZ_CP094755:c2533134-2532877 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240208 NZ_LS992180:c46795-46427 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References