Detailed information of TA system TA240206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2501295..2501479
• Replicon: chromosome
• Accession: NZ_CP094755
• Organism: Staphylococcus aureus strain IVB6242

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA32_RS12555
• Protein ID: WP_000482647.1
• Coordinates: 2501372..2501479 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2501295..2501355 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA32_RS12540	2496805..2496972	-	168	Protein_2425	hypothetical protein	-
MUA32_RS12545	2497203..2498936	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA32_RS12550	2498961..2500724	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2501295..2501355	+	61	-	-	Antitoxin
MUA32_RS12555	2501372..2501479	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA32_RS12560	2501613..2501999	-	387	WP_000779351.1	flippase GtxA	-
MUA32_RS12565	2502267..2503409	+	1143	WP_001176855.1	glycerate kinase	-
MUA32_RS12570	2503469..2504128	+	660	WP_262516001.1	hypothetical protein	-
MUA32_RS12575	2504310..2505521	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA32_RS12580	2505644..2506117	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240206 WP_000482647.1 NZ_CP094755:c2501479-2501372 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240206 NZ_LS992175:c4982339-4981965 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240206 NZ_CP094755:2501295-2501355 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin