Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475994..2476511 Replicon chromosome
Accession NZ_CP094755
Organism Staphylococcus aureus strain IVB6242

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA32_RS12420 Protein ID WP_000251928.1
Coordinates 2475994..2476260 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA32_RS12425 Protein ID WP_000584497.1
Coordinates 2476260..2476511 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA32_RS12395 (2471201) 2471201..2471737 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA32_RS12400 (2472205) 2472205..2473029 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA32_RS12405 (2473232) 2473232..2473414 - 183 WP_000079140.1 hypothetical protein -
MUA32_RS12410 (2473501) 2473501..2473968 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA32_RS12415 (2474154) 2474154..2475701 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA32_RS12420 (2475994) 2475994..2476260 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA32_RS12425 (2476260) 2476260..2476511 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA32_RS12430 (2476675) 2476675..2476775 - 101 Protein_2403 hypothetical protein -
MUA32_RS12435 (2476782) 2476782..2477381 - 600 WP_000162804.1 DsbA family protein -
MUA32_RS12440 (2477400) 2477400..2477762 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA32_RS12445 (2478017) 2478017..2479267 + 1251 WP_262515990.1 FemA/FemB family glycyltransferase FmhA -
MUA32_RS12450 (2479364) 2479364..2480095 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA32_RS12455 (2480092) 2480092..2480811 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240205 WP_000251928.1 NZ_CP094755:c2476260-2475994 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240205 NZ_LS992175:c4830697-4830338 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACCTGATTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAACAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTTCCGGGAAAGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240205 WP_000584497.1 NZ_CP094755:c2476511-2476260 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240205 NZ_LS992175:c4830348-4830031 [Citrobacter freundii]
ATGTCACATGATGTCGAAACCAGTAGCGGTAATGTTTACGCCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAGCTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGTTACTGGGAA
TGACACAGCCTAAACTTTCCAATCTGCTACGCGGCCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References