Detailed information of TA system TA240196

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1873243..1873423
• Replicon: chromosome
• Accession: NZ_CP094755
• Organism: Staphylococcus aureus strain IVB6242

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA32_RS08965
• Protein ID: WP_001801861.1
• Coordinates: 1873243..1873338 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1873366..1873423 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA32_RS08935	1868387..1869013	+	627	WP_000669038.1	hypothetical protein	-
MUA32_RS08940	1869054..1869398	+	345	WP_000627550.1	DUF3969 family protein	-
MUA32_RS08945	1869496..1870068	+	573	WP_000414222.1	hypothetical protein	-
MUA32_RS08950	1870217..1871584	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA32_RS08955	1871584..1872153	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA32_RS08960	1872346..1872792	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA32_RS08965	1873243..1873338	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1873366..1873423	-	58	-	-	Antitoxin
MUA32_RS08970	1873461..1873562	+	102	WP_001791232.1	hypothetical protein	-
MUA32_RS08975	1873737..1874180	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA32_RS08980	1874180..1874623	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA32_RS08985	1874623..1875065	-	443	Protein_1767	DUF1433 domain-containing protein	-
MUA32_RS08990	1875590..1878010	+	2421	WP_262515765.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240196 WP_001801861.1 NZ_CP094755:1873243-1873338 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240196 NZ_LS992173:c961-680 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240196 NZ_CP094755:c1873423-1873366 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin