Detailed information of TA system TA240188

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2501292..2501476
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA86_RS12560
• Protein ID: WP_000482647.1
• Coordinates: 2501369..2501476 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2501292..2501352 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS12545	2496802..2496969	-	168	Protein_2426	hypothetical protein	-
MUA86_RS12550	2497200..2498933	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA86_RS12555	2498958..2500721	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2501292..2501352	+	61	-	-	Antitoxin
MUA86_RS12560	2501369..2501476	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA86_RS12565	2501610..2501996	-	387	WP_000779351.1	flippase GtxA	-
MUA86_RS12570	2502264..2503406	+	1143	WP_001176855.1	glycerate kinase	-
MUA86_RS12575	2503466..2504125	+	660	WP_262516001.1	hypothetical protein	-
MUA86_RS12580	2504307..2505518	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA86_RS12585	2505641..2506114	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240188 WP_000482647.1 NZ_CP094752:c2501476-2501369 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240188 NZ_LS992171:c4019818-4019531 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240188 NZ_CP094752:2501292-2501352 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin