240187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475991..2476508 Replicon chromosome
Accession NZ_CP094752
Organism Staphylococcus aureus strain IVB6243

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag MUA86_RS12425 Protein ID WP_000251928.1
Coordinates 2475991..2476257 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag MUA86_RS12430 Protein ID WP_000584497.1
Coordinates 2476257..2476508 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA86_RS12400 (2471198) 2471198..2471734 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
MUA86_RS12405 (2472202) 2472202..2473026 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA86_RS12410 (2473229) 2473229..2473411 - 183 WP_000079140.1 hypothetical protein -
MUA86_RS12415 (2473498) 2473498..2473965 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA86_RS12420 (2474151) 2474151..2475698 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA86_RS12425 (2475991) 2475991..2476257 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
MUA86_RS12430 (2476257) 2476257..2476508 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA86_RS12435 (2476672) 2476672..2476772 - 101 Protein_2404 hypothetical protein -
MUA86_RS12440 (2476779) 2476779..2477378 - 600 WP_000162804.1 DsbA family protein -
MUA86_RS12445 (2477397) 2477397..2477759 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA86_RS12450 (2478014) 2478014..2479264 + 1251 WP_262515990.1 FemA/FemB family glycyltransferase FmhA -
MUA86_RS12455 (2479361) 2479361..2480092 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
MUA86_RS12460 (2480089) 2480089..2480808 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T240187 WP_000251928.1 NZ_CP094752:c2476257-2475991 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240187 NZ_LS992171:3691567-3691845 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT240187 WP_000584497.1 NZ_CP094752:c2476508-2476257 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT240187 NZ_LS992171:3691304-3691564 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References