Detailed information of TA system TA240185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2212907..2213123
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: MUA86_RS11055
• Protein ID: WP_073392962.1
• Coordinates: 2213019..2213123 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2212907..2212962 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS11030	2209101..2209766	-	666	WP_001024099.1	SDR family oxidoreductase	-
MUA86_RS11035	2209918..2210238	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MUA86_RS11040	2210240..2211220	+	981	WP_262515911.1	CDF family zinc efflux transporter CzrB	-
MUA86_RS11045	2211486..2212577	+	1092	WP_000495684.1	hypothetical protein	-
-	2212907..2212962	+	56	-	-	Antitoxin
MUA86_RS11055	2213019..2213123	-	105	WP_073392962.1	hypothetical protein	Toxin
MUA86_RS11060	2213803..2213961	+	159	WP_001792784.1	hypothetical protein	-
MUA86_RS11065	2214620..2215477	-	858	WP_000370937.1	HAD family hydrolase	-
MUA86_RS11070	2215545..2216327	-	783	WP_262515912.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T240185 WP_073392962.1 NZ_CP094752:c2213123-2213019 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T240185 NZ_LS992171:3472803-3473021 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT240185 NZ_CP094752:2212907-2212962 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin