Detailed information of TA system TA240178

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1873240..1873420
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA86_RS08965
• Protein ID: WP_001801861.1
• Coordinates: 1873240..1873335 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1873363..1873420 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS08935	1868384..1869010	+	627	WP_000669038.1	hypothetical protein	-
MUA86_RS08940	1869051..1869395	+	345	WP_000627550.1	DUF3969 family protein	-
MUA86_RS08945	1869493..1870065	+	573	WP_000414222.1	hypothetical protein	-
MUA86_RS08950	1870214..1871581	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA86_RS08955	1871581..1872150	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
MUA86_RS08960	1872343..1872789	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA86_RS08965	1873240..1873335	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1873363..1873420	-	58	-	-	Antitoxin
MUA86_RS08970	1873458..1873559	+	102	WP_001791232.1	hypothetical protein	-
MUA86_RS08975	1873734..1874177	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA86_RS08980	1874177..1874620	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA86_RS08985	1874620..1875062	-	443	Protein_1767	DUF1433 domain-containing protein	-
MUA86_RS08990	1875587..1878007	+	2421	WP_262515765.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240178 WP_001801861.1 NZ_CP094752:1873240-1873335 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240178 NZ_LS992171:c1801922-1801545 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT240178 NZ_CP094752:c1873420-1873363 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin