Detailed information of TA system TA240173

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 356780..357118
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA86_RS01645
• Protein ID: WP_072357969.1
• Coordinates: 356780..356956 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	356944..357118 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS01615	352054..352344	+	291	WP_000179864.1	hypothetical protein	-
MUA86_RS01620	352360..354270	+	1911	WP_262516146.1	hypothetical protein	-
MUA86_RS01625	354270..355736	+	1467	WP_045179073.1	BppU family phage baseplate upper protein	-
MUA86_RS01630	355736..356125	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA86_RS01635	356118..356282	+	165	WP_262516148.1	XkdX family protein	-
MUA86_RS01640	356328..356627	+	300	WP_000466774.1	DUF2951 family protein	-
MUA86_RS01645	356780..356956	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	356944..357118	-	175	-	-	Antitoxin
MUA86_RS01655	357400..359046	+	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
MUA86_RS01665	360759..361061	+	303	WP_000339141.1	phage holin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	314260..362526	48266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T240173 WP_072357969.1 NZ_CP094752:356780-356956 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T240173 NZ_LS992171:712846-713142 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT240173 NZ_CP094752:c357118-356944 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin